Amy Schumer Says Comments About Her 'Moon Face' Led to Cushing Syndrome Diagnosis: 'I Wouldn't Have Known'

Amy Schumer says she wouldn’t have known she had Cushing syndrome if it weren’t for Internet trolls.

“A year ago, the Internet really came for me,” Schumer, 43, told Alex Cooper on the Jan. 22 episode of the Call Her Daddy podcast, sharing that commenters were criticizing her suddenly swollen face.

Schumer says she ignored the comments at first — “I was like, ‘Okay, everybody, like, relax’ ” — until physicians began to comment with possible diagnoses for Schumer, all based on her appearance. “Doctors were chiming in in the comments and they were, like, ‘No, no … something's really up. Your face looks so crazy.’ “

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The Trainwreck star said doctors thought she might have Cushing syndrome, which as the Mayo Clinic explains, occurs when the stress hormone, cortisol, remains in the body for too long. It's caused by taking steroids for an extended period of time and can cause weight gain, acne — and distinctive facial swelling that’s called a “moon face.”

“At first, I was like, ‘F—k off,’ “ Schumer said, until she realized “Wait, I have been getting steroid injections for my scars” from her breast reduction and Cesarean section.  (Schumer and husband Chris Fischer welcomed son Gene, 5, in 2019.)

“So I got these was getting these steroid injections and so it gave me this thing called Cushing syndrome — which I wouldn't have known if the internet hadn't come for me so hard,” explained Schumer, who first shared her Cushing diagnosis in February 2024.

Related: Amy Schumer Posts Photo from Gynecologist's Office with Her Feet in Stirrups: 'I'm Fine'

The comic told Cooper that right before she began shooting the comedy Kinda Pregnant, which premieres on Netflix Feb. 5, “I learned I had this condition, and that I had something called moon face, and I'm starring in a movie — and there's a camera right in my face.”

“Everyone's like, ‘You look great,’ ” she said, until one friend gave her the blunt truth, telling Schumer, “Your face is looking, like, a little bit insane.”

Schumer explained that she “got rid” of Cushing, telling Cooper “it just has to work itself out,” but before she began filming, she was worried about her on-screen appearance, saying, “I was feeling really down on myself before I started filming this movie … I was, like, really having trouble figuring out how I was going to star in a movie while I had this going on.”

She said it took one friend, director Lorraine Caffery, who told her, “ ‘You know, I think you look f—ing great.”

“I just needed one person to just amp me up.”

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