Sean Penn and Charlize Theron Split

Sean Penn and Charlize Theron debuted their romance in 2013. Photo: Getty

After starting a romance in 2013, Charlize Theron and Sean Penn have split, an insider confirms to WHO.

Nearly inseparable since getting together, often spending time with Theron's 3-year-old son, Jackson, the couple was last seen looking stunning on the Cannes red carpet in May.

But in recent weeks, the couple weren't spotted together at all. According to sources, they stayed under separate roofs: Theron and son Jackson remained at their Hollywood home and Penn at his Malibu mansion, which he had put up for sale but recently pulled off the market. They backed out of at least one scheduled event together before Theron headed to London to film The Huntsman.

Reps for the stars haven't commented at this time.

Charlize Theron introduced Penn to her son, Jackson, 3. Photo: Getty

When not promoting her film Mad Max, Theron, 39, and Penn, 54, spent time away from the spotlight, enjoying family time with Jackson on the French Riviera.

Sean Penn and Charlize Theron debuted their romance in 2013. Photo: Getty

Penn was spotted solo in the Brentwood section of Los Angeles Tuesday (US), purchasing magazines and cigarettes from a local newsstand.

Just last month Theron raved about her partner to British Elle, calling Penn the "love of my life."

"Putting aside that he's my partner, he's the love of my life; for the first time, I felt that my work was really bleeding into my life, and that made it hard," she told the magazine.

Rumours of a romance first began in 2010 but the duo were first photographed spending the New Year together in Hawaii.

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