Jamie-Lynn Sigler Says 'Beautiful and Healthy and Perfect' People Are 'Abusing' Ozempic

On her podcast MeSsy with Christina Applegate, Sigler, who struggled with an eating disorder as a teen, says the popularity of the weight-loss drug is "triggering"

<p>Scott Gries/BRAVO via Getty Images</p> Jamie Lynn Sigler in 2023.

Scott Gries/BRAVO via Getty Images

Jamie Lynn Sigler in 2023.

Jamie-Lynn Sigler admits that she feels "triggered" by the popularity of the drug Ozempic, which is intended for type 2 diabetes but is being widely used off-label for weight loss.

On the new episode of MeSy, Sigler's podcast with Christina Applegate, the actress said the ubiquity of the drug has all but derailed the body positivity movement.

"I'm annoyed at myself that I'm admitting this and I'd like to get to the bottom of why I'm a little triggered about all the Ozempic stuff. It's upsetting me. I wish I didn't care," Sigler, 42, told Applegate. The reason behind her upset is because "it felt like we were on this road to solidifying body positivity, and every shape and size and color, and everyone's looking the same now."

<p><a href="https://www.instagram.com/johnrussophoto/?hl=en" data-component="link" data-source="inlineLink" data-type="externalLink" data-ordinal="1">John Russo</a></p> Christina Applegate and Jamie-Lynn Sigler photographed for PEOPLE in March 2024.

John Russo

Christina Applegate and Jamie-Lynn Sigler photographed for PEOPLE in March 2024.

Related: Christina Applegate Reveals She Struggled with Anorexia on Married with Children: 'I Wanted My Bones to Be Sticking Out'

Sigler, who along with Applegate shared their past experiences with eating disorders in the same episode, said she has friends who have been helped by the drug — friends who she's seen "struggle with their weight for a very, very, very long time. I've seen it give them a lot and I am so happy for them."

But, The Sopranos actress said she knows other people taking it who simply don't need it: "I have also seen friends of mine. who were beautiful and healthy and perfect, abusing it, and it’s upsetting me."

Applegate, who has bonded with Sigler over the fact that they both are living with multiple sclerosis, agreed, saying "People are, you know, fading away," then jokingly added this cautionary note: "For women out there listening, the thinner your face is, the older you look, okay? Not that looking old is bad!...Aging gracefully is beautiful."

<p>Wishbone Production</p> Christina Applegate and Jamie-Lynn Sigler's podcast, MeSsy.

Wishbone Production

Christina Applegate and Jamie-Lynn Sigler's podcast, MeSsy.

Related: Stars Who've Spoken About Ozempic — and What They've Said

The Dead to Me actress, who said she gained 45 lbs. after her 2021 MS diagnosis for multiple sclerosis, is still struggling with the changes in her own body due to the disease: "I don't look in mirrors. I have writing all over my mirrors in my bathroom so that I don't look in them...Because I will like fall on the ground and cry. That's how I feel now."

But Applegate, who said in her teen years when she was struggling with anorexia on Married with Children she would sometimes live on "five almonds a day," said she doesn't have unrealistic expectations for her body — she just wants to fit into her old clothes. "I don't need to be thin," she said.

"I'm not working. I have a closet full of clothes that I can't wear, and I have no money coming in. I don't want to spend money on new clothes. I would just like to wear the ones that I already own."

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