“They Couldn't Shoot My Face”: Margaret Qualley Said Her Prosthetics For “The Substance” Gave Her Such Bad Acne That It Took A Year For Her To “Physically” Recover

By now, you’ll have definitely heard about The Substance — one of the most talked-about movies of the year.

Demi Moore sitting on a couch in elegant attire. A large photo of her in a belted swimsuit hangs behind
MUBI / Courtesy Everett Collection

It’s the critically acclaimed body horror thriller starring Demi Moore as an aging Hollywood star who takes a black-market drug called the Substance, which spawns a younger, “better” version of herself called Sue, played by Margaret Qualley.

Demi with long dark hair looks at her reflection in a tiled bathroom mirror, wearing a dark top, appearing contemplative
Demi with long dark hair looks at her reflection in a tiled bathroom mirror, wearing a dark top, appearing contemplative
Margaret in strapless dress smiles during a TV interview against a cityscape backdrop
Margaret in strapless dress smiles during a TV interview against a cityscape backdrop

MUBI / Courtesy Everett Collection

Demi just won a well-deserved Golden Globe for her performance as Elisabeth Sparkle — and looks likely to score an Oscar nomination, too.

The Substance cleverly examines themes of toxic beauty standards, and even if you’ve not seen it yet, you’ll probably have heard that there are a ton of very graphic scenes involving blood, nudity, and body disfigurement.

A peerson in a luxurious robe with a gold design stands over another person who is nude lying on a bathroom floor, back stitched like a seam
MUBI / Courtesy Everett Collection

Impressively, the film relies primarily on practical effects rather than CGI. However, this did mean that both Demi and Margaret spent a lot of time in the makeup chair while shooting was underway.

Demi and Margaret  stand together on stage at an event. One wears a white dress with a black bow; the other wears a sleek strapless gown, smiling at the audience
Christopher Polk / Penske Media via Getty Images

Around the time of the film’s release in September, Demi told Entertainment Weekly about the grueling process, revealing some shoot days began with over nine hours of prosthetics work — with up to 14 pieces “glued” to just her face alone.

Demi is being prepared for a performance with makeup and a bald cap, assisted by a team
Demi is being prepared for a performance with makeup and a bald cap, assisted by a team
Makeup artists apply prosthetics to Demi's face, creating an aged appearance for a film or TV production
Makeup artists apply prosthetics to Demi's face, creating an aged appearance for a film or TV production

MUBI / YouTube / Via youtu.be

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In the same interview, she also talked about the risk of damage to her skin, particularly during the hour-and-a-half removal process, saying: “You have to be as careful if not more careful taking it off so you don't destroy your skin.”

And now, Margaret has opened up about her prosthetics experience and the long-term impact it had on her skin.

Margaret with long dark hair and jeweled earrings poses on a red carpet in an elegant dress, looking over her shoulder
Matt Winkelmeyer / WireImage

Speaking to Josh Horowitz on the latest episode of his Happy Sad Confused podcast, Margaret revealed that her face had to be cropped out of certain shots that were filmed toward the end of the shoot because, by that time, she’d developed such bad “acne from the prosthetics.”

Margaret sitting, getting special effects makeup applied to their head and neck by a makeup artist, creating an alien-like appearance
Margaret sitting, getting special effects makeup applied to their head and neck by a makeup artist, creating an alien-like appearance
Margaret sitting in a chair getting special effects makeup applied, surrounded by three artists working on prosthetics
Margaret sitting in a chair getting special effects makeup applied, surrounded by three artists working on prosthetics

MUBI / YouTube / Via youtu.be

“When they’re shooting up my skirt in the beginning credits when it’s like the palm trees all around, and they have all these long lenses from the bottom, that’s just because my face was so fucked up by that time that they couldn’t shoot my face anymore,” she said, letting out a laugh.

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Margaret joked that it was kind of ironic that she was “covered” with acne, being that her character is meant to be the embodiment of societal feminine perfection.

Noting that it took “a year to recover, physically,” Margaret said her skin problems lingered while she was shooting her next movie, Yorgos Lanthimos’s Kinds of Kindness. But because she was playing four different characters in the film, she said the acne was “kind of perfect.”

Margaret smiling, wearing a sleeveless elegant dress with beaded details and long earrings, on a red carpet event

You can watch Margaret’s full appearance on the Happy Sad Confused podcast here.

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