Right-back James will not feature on the final day after aggravating a hamstring injury this week, capping a season which has been plagued by fitness issues for the 23-year-old.
“I’m sure you’ve seen the news,” he posted on Instagram. “I won’t be back for the last game of the season.
“It’s been tough for me. I’m sorry this season hasn’t gone as we all wanted.”
Mauricio Pochettino is tipped to take charge of Chelsea next season, when James is expected to have recovered from his injury.
The England defender finished off his message with an optimistic look to the future.
He continued: “Next season I’ll be back stronger than ever, and we’ll be back fighting for trophies! Stay well and see you soon. Love you all.”