A hugely controversial late penalty saw Newcastle drop two vital points in the Champions League at Paris Saint-Germain in midweek.
Both teams have fared better in domestic matters this term, with this a clash of sixth and seventh that has the Red Devils a point above their opponents ahead of kick-off.
Erik ten Hag's side can boast five wins in their last six in the league and yet this promises to be a far tougher examination, given all of those victories came against sides in the bottom half of the table.
Date, kick-off time and venue
Newcastle vs Manchester United is scheduled for an 8pm GMT kick-off tonight on Saturday December 2, 2023.
The match will take place at St James' Park in Newcastle.
Where to watch Newcastle vs Manchester United
TV channel: In the UK, tonight's game will be televised live on TNT Sports 1, with coverage beginning at 7pm.
Live stream: Subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Newcastle vs Manchester United team news
Eddie Howe's substantial injury list does not ease this weekend, with Sean Longstaff still ruled out of action.
The likes of Callum Wilson, Dan Burn, Harvey Barnes, Joe Willock, Jacob Murphy, Elliot Anderson, Javier Manquillo, Matt Targett and Sven Botman all remain at least weeks away from a return. Sandro Tonali, meanwhile, is banned from football until August.
Newcastle could bring Lewis Hall into the mix for fresh legs after Howe left his youthful bench untouched in Paris.
Teenage midfielder Kobbie Mainoo is pushing for another start in the Manchester United team having returned to the bench in Istanbul in midweek despite shining against Everton.
Casemiro leads the visitors' list of absentees, which includes the likes of Lisandro Martinez, Christian Eriksen, Jonny Evans, Amad Diallo and Mason Mount.
Tyrell Malacia has suffered a setback in training, while Jadon Sancho remains unavailable.
Newcastle vs Manchester United prediction
The Magpies have one of the best home records in the league, and while the Red Devils are strong on the road domestically they tend not to score often - which will worry them against a very solid defence.
Their best bet is Newcastle are exhausted and impacted by their injuries, something which they've dealt with well in the last couple of games.
Newcastle to win, 1-0.
Head to head (h2h) history and results
Manchester United have failed to score in three of their last four meetings with Newcastle, winning one of the last five.
Newcastle wins: 45
Man Utd wins: 91
Newcastle vs Manchester United match odds
Newcastle to win: Evens
Man Utd to win: 5/2
Odds via Betfair (subject to change).