Jake Trbojevic's push to return in time for State of Origin has come back to haunt him, with the Manly star ruled out for six weeks with a fresh calf injury.

Trbojevic returned ahead of the initial schedule from a calf injury for the Sea Eagles' win over Canberra on Sunday, before leaving the field in the second half.

That prompted him to withdraw from Origin I calculations on the night the team was selected, before scans showed he has again torn his calf.

Trbojevic is now not expected to return before the end of the Origin series with Manly set to be without their best forward until the end of next month.

Trbojevic's brother Ben is also set for a long period on the sidelines after suffering his second hamstring tear of the year early in the Raiders match.

It comes as the Sea Eagles battle a serious injury crisis in their pack.

Josh Aloiai will miss a second straight match against Newcastle on Sunday after a dislocated shoulder, but Manly are hopeful he will return after the round-14 bye.

Kelma Tuilagi (facial fracture), Aaron Woods (wrist) and Zac Fulton (elbow) are also out for several more weeks.