The Queen of Pop will visit 35 cities during Madonna: The Celebration Tour, which has been billed as a "one-of-a-kind experience".
The much-anticipated tour will include five nights at London's O2 Arena. Here's how you can get tickets.
How to buy tickets to see Madonna in London
Madonna will bring her Celebration Tour to London's O2 Arena on 14, 15, 17 and 18 October, and 5 December.
The concerts will be the pop icon's first performances in the UK since her 12-date residency at the London Palladium in early 2020.
Madonna, who has 13 UK number one singles, is expected to perform some of biggest hits from her extensive career.
The Vogue singer, 64, said: "I am excited to explore as many songs as possible in hopes to give my fans the show they have been waiting for."
Promoters said the tour, named after her 2009 hit Celebration, will explore "Madonna's artistic journey through four decades".
It will also feature special guest Bob the Drag Queen, best known for winning Ru Paul's Drag Race.
Madonna announced the news of the tour with a star-studded promotional video featuring Jack Black, Amy Schumer, Diplo and Lil Wayne.
See Madonna's full list of London concert dates below:
14 October – O2 Arena
15 October – O2 Arena
17 October – O2 Arena
18 October – O2 Arena
5 December – O2 Arena
Last year, Madonna marked the 40th anniversary of her recording debut and released a new compilation album titled Finally Enough Love: 50 Number Ones.
Her most recent studio album, Madame X, was released in 2019 and reached number two on the UK chart.
The singer has reportedly sold more than 300 million records worldwide, and was inducted into the Rock & Roll Hall of Fame in 2008.
Earlier this week, it was reported that Madonna's long-anticipated biopic has been shelved.
She was preparing to direct the film, which was due to star Julia Garner, but the world tour means the project has been put on an indefinite hiatus.
Watch: Madonna thanks fans for support after announcing tour