The Hatters fell at this stage last season but at least have home advantage, and Kenilworth Road will be rocking with the knowledge that a victory by two goals will send them to Wembley for a meeting with Middlesbrough or Coventry.
It could also be a long night however, with a one-goal Luton win sending the tie to extra-time and potentially penalties.
For two clubs who have dragged themselves out of the lower leagues to knock on the door of the top flight, this is the mother of all games.
Where to watch Luton vs Sunderland
TV channel: In the UK, the game will be broadcast live on Sky Sports Football and Main Event, with coverage starting at 7.30pm BST before an 8pm kick-off.
Live stream: Sky Sports subscribers can watch the game online via the Sky Go app.