The pair was being interviewed in celebration of their 20-year working relationship.
However, the show infamously hinted that Kyle had a startling health confession to make only to show he was joking around when the show actually aired.
During the interview, Kyle was in tears as he told Jackie O: "There’s a condition that I’ve been diagnosed with that I haven’t spoken to anyone about."
When she questioned if he was joking, he quickly responded, "Yeah," and burst into laughter leaving viewers, Jackie O and Karl less than impressed.
"There’s nothing wrong with me," he later clarified.
"Why would you do that?" Jackie said, calling the stunt ‘emotionally mean’ and ‘cruel’.
"One thing for @kyleandjackieo to pull a prank about a life threatening illness," Peter Ford tweeted at the time. "That’s on brand. Different thing for @60Mins to use it in a promo knowing they wouldn’t be delivering. That’s off brand.
"Anybody who has ever been diagnosed with terminal cancer, and had to tell loved ones, would not appreciate Kyle Sandiland’s ‘joke’ tonight," Derryn Hinch added.
Now, Kyle has revealed he was, in fact, high on marijuana during the interview.
"I was off my head," Kyle told News.com.au.
Jackie agreed with him, adding, "I almost died. He arrived late to that interview. We were waiting 50 minutes for him."
"I was probably dutching it up in the car," Kyle laughed.
Jackie told the publication she was aware as soon as Kyle walked in the room.
After the episode aired last year, Kyle broke down in tears, this time saying the reason he was crying on the show was that he was very close to opening up about his mental health struggles.
"The honest truth of why I was about to cry with all that breakdown stuff is because inside, I’m very, very sad," Kyle said. "But it wasn’t the right forum to bring it up.
"When you said, 'I’m very worried about him'. A wave of emotion went through me, and I realised I was losing control, so I had to make something up as a joke."
"(People) look at me and think, ‘yeah, you’re a fat b*****d, you should be sad’," he said.
"Me, knowing how I feel inside, watching the show last night … there were glimpses of (the sadness). Like, when Karl was like, ‘do you use humour to mask sadness?’ That is true. I use jokes and say inappropriate things.
"I just feel really let down by a lot of people, a lot of the time. Everyone has their struggles – but I often feel very alone."
Both Kyle and Jackie O were in tears with Jackie reminding him she is always there for him.
Yahoo Lifestyle has contacted Nine for comment.
Mental health support for yourself or a loved one can be found by calling Lifeline on 13 11 14, Mensline on 1300 789 978, or the Kids Helpline on 1800 551 800. Online support is available via Beyond Blue.
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