The Gunners were confidently knocked out by Brighton at this stage last season and face a tricky trip to the west of London fearing the same fate.
Brentford, though, are licking their wounds after a rare home defeat last time out against Everton but Thomas Frank will have his players charged up for a huge cup derby under the lights.
Date, kick-off time and venue
Brentford vs Arsenal is scheduled for a 7.45pm BST kick-off tonight on Wednesday, September 27, 2023.
The match will take place at the Gtech Community Stadium.
Where to watch Brentford vs Arsenal
TV channel and live stream: In the UK, the game will not be televised live.
Live blog: However, you can follow all the action via Standard Sport’s live blog, with expert analysis from Simon Collings at the ground.
Brentford vs Arsenal team news
Brentford XI: Flekken, Roerslev, Collins, Zanka, Pinnock, Hickey, Onyeka, Norgaard, Janelt, Mbeumo, Wissa
Subs: Strakosha, Balcombe, Jensen, Ghoddos, Ajer, Lewis-Potter, Yarmoliuk, Olakigbe, Brierley
Arsenal XI: Ramsdale; Tomiyasu, White, Gabriel, Kiwior; Jorginho, Havertz, Smith Rowe; Nelson, Sagoe Jr, Nketiah
Subs: Hein, Cedric, Sweet, Walters, Zinchenko, Elneny, Odegaard, Cozier-Duberry, Jesus
Brentford vs Arsenal prediction
This should be a really intriguing derby, against a team able to exploit possible weaknesses in Arsenal’s midfield.
But, as stated above, I expect both teams to make changes and the Gunners have the greater strength in depth.
Arsenal to win, 3-1 in normal time.
Head to head (h2h) history and results
Arsenal have lost just one of the last eight meetings between the two teams, a run dating back to the 1930s.
Brentford wins: 6
Arsenal wins: 6
Brentford vs Arsenal match odds
Gabriel Jesus to score: 11/10
Odds via Betfair (subject to change).