A single-goal lead has the Italians in the driving seat in this Europa League semi-final tie, with the winner to face Juventus or Sevilla in the final.
Roma’s effervescent coach has lifted the Champions League twice as well as this competition once, while he guided the Giallorossi to the Europa Conference League a year ago.
But he must get the better of the up-and-coming Xabi Alonso, who has deeply impressed in his burgeoning managerial career.
Having led Leverkusen away from the Bundesliga dropzone, the former midfielder could really mark his name out as one to watch by securing a ticket to the Europa League final with a comeback later today.
Where to watch Bayer Leverkusen vs Roma
TV channel: In the UK, the game will be televised live on BT Sport 3, with coverage beginning at 7.45pm for an 8pm BST kick-off.
Live stream: Subscribers can also catch the contest live online via the BT Sport app and website.