The striker missed training on Tuesday afternoon with a knock and his absence leaves Arsenal short on attacking options, with Gabriel Jesus already out.
Kai Havertz was an option to step up and lead the line, but he stays in midfield and Leandro Trossard gets the nod through the middle in the front three. Takehiro Tomiyasu keeps his place at left-back, with Oleksandr Zinchenko on the bench.
Captain Martin Odegaard misses the game at the Emirates Stadium too. The midfielder has been struggling with a hip issue and missed Saturday’s defeat by Newcastle.
Arsenal have a number of injuries at the moment to key players and Jesus is still out, despite being called up by Brazil for international duty on Monday.
The striker has a hamstring issue and has not played since Arsenal won in Seville last month.
The Gunners are also without Emile Smith Rowe (knee), Jurrien Timber (knee) and Thomas Partey (hip) for Wednesday’s game against Sevilla.
Arsenal XI: (4-3-3): Raya; White, Saliba, Gabriel, Tomiyasu; Jorginho, Rice, Havertz; Saka, Trossard, Martinelli
Subs: Ramsdale, Hein, Cedric, Kiwior, Zinchenko, Vieira, Nelson, Elneny, Cozier-Duberry, Sagoe Jr
Time and date: 8pm GMT on Wednesday, November 8, 2023
Venue: Emirates Stadium