Wolves' stunning late show has rocked Tottenham and denied Ange Postecoglou's side the chance to return to the top of the Premier League.
Instead, following Spurs' 2-1 defeat at Molineux courtesy of two stoppage-time goals on Saturday, Arsenal have moved level on points with Premier League leaders Manchester City after a 3-1 home win over Burnley.
Like Spurs, Newcastle were also left shocked on their away-day by losing 2-0 at struggling Bournemouth.
In the lunchtime kick-off, Pablo Sarabia and Mario Lemina both scored in stoppage time as Wolves snatched a thrilling - but deserved - victory over Postecoglou's side, just 24 hours after he'd picked up as third straight manager-of-the-month award.
Brennan Johnson's early strike - his first Spurs goal - had given the visitors the lead and they looked on course for a smash-and-grab win at Molineux.
Tottenham rode their luck as Wolves constantly let them off the hook until Sarabia - with a quite dazzling 91st minute equaliser featuring instant control and a brilliant volley - and Lemina, in the 97th minute, sparked the sensational finish.
Spurs were heading two points clear at the top of the table but have now suffered successive defeats, in what has proved the toughest week yet for their Australian boss, who had to deal with suspensions and injuries to assemble a patchwork squad.
Ukrainian Oleksandr Zinchenko was Arsenal's hero, scoring a fine goal as the 10-man Gunners secured a comfortable win, but had to respond to an early setback in the second half.
Leandro Trossard put Arsenal ahead in first-half stoppage time when he turned home Bukayo Saka's header from close range, but crashed into the frame of the goal in the process.
Vincent Kompany's struggling Burnley levelled after the break when Josh Brownhill's deflected shot survived a VAR check, but a header from William Saliba three minutes later restored Arsenal's lead and Zinchenko's acrobatic finish from another corner sealed the points, despite a late red card for Fabio Vieira.
Manchester United rallied following their midweek Champions League defeat in Copenhagen with another battling victory after Victor Lindelof struck the only goal against Luton.
The pressure was on Erik ten Hag's side and after pre-match fan protests against United owners the Glazer family, the visiting Hatters made life difficult for the Red Devils before Lindelof lashed home from close range after a cross by Marcus Rashford.
Newcastle boss Eddie Howe endured a night to forget at old club Bournemouth after a brace from Dominic Solanke earned the hosts a priceless 2-0 win.
Cherries manager Andoni Iraola had to wait until his 10th Premier League match for a maiden victory in the division, but back-to-back home successes have now moved them out of the bottom three.
Solanke fired in the opener at Nick Pope's near post after 59 minutes before making the result safe when he flicked home from a corner with 17 minutes left.
Everton continued their push up the table under Sean Dyche as they edged a thriller 3-2 at Crystal Palace thanks to Idrissa Gueye's 86th-minute winner.