Villarreal and Alaves have enjoyed massive wins against lower-division opposition in the Copa del Rey as all of the favourites advanced in the competition.
Alaves routed seventh-tier Deportivo Murcia 10-0 with Jon Karrikaburu scoring a hat-trick and three other players finding the net twice - Abde Rebbach, Xeber Alkain and Ianis Hagi.
Villarreal defeated sixth-tier Chiclana 5-0 with a hat trick by Manu Trigueros.
Granada also advanced, beating fifth-tier Arosa 3-0, though the win was being contested because of accusations they fielded an ineligible player.
Valencia defeated fourth-tier Logrones 2-0.
Two games between lower-division clubs were postponed because of bad weather - Sestao River at Gimnastica Segoviana and Real Zaragoza at Atzeneta.
The first round was played in single elimination games at the home of the lower-division teams.